<button id="eiezk"><video id="eiezk"></video></button>

產(chǎn)品名稱(chēng)

ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride

產(chǎn)品貨號(hào)

Axon 2888 CAS [912445-05-7] MF C13H1N4O.2HClMW 317.21 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. The free base of ABT 888 is available as Axon 1893. KEYWORDS: ABT 888 dihydrochloride | supplier | PARP inhibitor | Veliparib dihydrochloride | A 861695 dihydrochloride | A861695 dihydrochloride | A-861695 dihydrochloride | CAS [912445-05-7] | [912444-00-9] | DNA-RNA | PARP | Inhibitor | Enzymes

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride

Based on 8 reference(s) in Google Scholar 8 10 8

Axon 2888

CAS [912445-05-7]

MF C13H1N4O.2HCl
MW 317.21

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

ABT 888 dihydrochloride

Description

Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.

The free base of ABT 888 is available as Axon 1893.

CK Donawho et al. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models. Clin. Cancer Res. 2007, 13, 2728.

P Palma et al. The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo. Anticancer Res. 2008, 28(5A), 2625-2635.?

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 2.4.2.30 PARP

PARP inhibitor

Chemical name

(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride

Parent CAS No.

[912444-00-9]

產(chǎn)品資料

<button id="eiezk"><video id="eiezk"></video></button>