| 產(chǎn)品名稱 | TH 287 hydrochloride |
| 產(chǎn)品貨號(hào) | Axon 2271 CAS [N.A.] MF C11H10Cl2N4.HClMW 305.59 Purity: 98% Soluble in DMSO Description First-in-class MTH1 inhibitor (IC50 value 0.8 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells. TH 287 shows no relevant inhibitory effect for any of the other tested nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, nor for other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase and ITPA). References Certificates Categories Extra info H. Gad et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 2014, 508, 215-221. ? Y. Nakabeppu et al. MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides. DNA Repair 2006, 5, 761-772. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology DNA-damage Response MTH1 EC 3.6.1.56 First-in-class MTH1 inhibitor Chemical name 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride Parent CAS No. [N.A.] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
TH 287 hydrochlorideAxon 2271 CAS [N.A.] MF C11H10Cl2N4.HCl
Description
First-in-class MTH1 inhibitor (IC50 value 0.8 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.
TH 287 shows no relevant inhibitory effect for any of the other tested nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, nor for other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase and ITPA).
First-in-class MTH1 inhibitor
Chemical name6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride Parent CAS No.[N.A.] |
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