| 產(chǎn)品名稱 | iCRT14 - CRT Inhibitor iCRT14 |
| 產(chǎn)品貨號(hào) | Axon 2135 CAS [677331-12-3] MF C21H17N3O2SMW 375.44 Purity: 98% Soluble in DMSO Description Small-molecule inhibitor of the Wnt/wingless signaling pathway (IC50 value 40 nM in a Wnt responsive STF16-luc reporter assay) that antagonizes the transcriptional function of nuclear β-catenin, and inhibits direct interactions between β-cat and TCF4. iCRT 14 exhibits specific cytotoxicity towards human colon tumor biopsy cultures as well as colon cancer cell lines that exhibit deregulated Wnt signaling. Similar mode of action as iCRT5 (Axon 2133) References Certificates Categories Extra info FC Gonsalves et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA? 2011, 108, 5954-5963.?? ? BA Narayanan et al. Antagonistic Effect of Small-molecule Inhibitors of Wnt/β-catenin in Multiple Myeloma. Anticancer Res. 2012, 32(11), 4697-4707.? ? JN Anastas & RT Moon. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 2013,?13, 11-26.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Wnt Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor Chemical name 5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-3-phenylthiazolidine-2,4-dione Parent CAS No. [677331-12-3] Order Size Unit Price Stock 10 mg €135.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
iCRT14 - CRT Inhibitor iCRT14Axon 2135 CAS [677331-12-3] MF C21H17N3O2S
DescriptionSmall-molecule inhibitor of the Wnt/wingless signaling pathway (IC50 value 40 nM in a Wnt responsive STF16-luc reporter assay) that antagonizes the transcriptional function of nuclear β-catenin, and inhibits direct interactions between β-cat and TCF4. iCRT 14 exhibits specific cytotoxicity towards human colon tumor biopsy cultures as well as colon cancer cell lines that exhibit deregulated Wnt signaling. Similar mode of action as iCRT5 (Axon 2133)
Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor
Chemical name5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-3-phenylthiazolidine-2,4-dione Parent CAS No.[677331-12-3] |
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