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產(chǎn)品名稱

KYA1797K

產(chǎn)品貨號

Axon 2668 CAS [1956356-56-1] MF C17H11KN2O6S2MW 442.51 Purity: 99% Soluble in DMSO Description Promotor of β-catenin and Ras degradation (IC50 value 0.75 μM for inhibition of TOPflash activity) that effectively suppresses the growth of CRCs (colorectal cancers) harboring APC and KRAS mutations in vitro and in vivo. KYA1797K binds the RGS domain of axin and enhances the binding affinity of β-catenin or Ras with the β-catenin destruction complex components, leading to simultaneous destabilization of β-catenin and Ras via GSK3β activation. KYA1797 also inhibits ASK1 (IC50 value 0.65 μM for inhibition of apoptosis signal-regulating kinase 1). ? KEYWORDS: KYA1797K | supplier | dual ASK1 and Wnt/β-catenin inhibitor | KYA 1797K | CAS [1956356-56-1] | [ 851304-36-4] | Wnt Inhibitor | Axin | Axin1 | RGS domain | Ras | GSK3β activation | ASK1 | apoptosis signal-regulating kinase 1 | colorectal cancer | CRC | APC

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

KYA1797K

Based on 2 reference(s) in Google Scholar 9 10 2

Axon 2668

CAS [1956356-56-1]

MF C17H11KN2O6S2
MW 442.51

Purity: 99%
Soluble in DMSO

KYA1797K

Description

Promotor of β-catenin and Ras degradation (IC50 value 0.75 μM for inhibition of TOPflash activity) that effectively suppresses the growth of CRCs (colorectal cancers) harboring APC and KRAS mutations in vitro and in vivo. KYA1797K binds the RGS domain of axin and enhances the binding affinity of β-catenin or Ras with the β-catenin destruction complex components, leading to simultaneous destabilization of β-catenin and Ras via GSK3β activation. KYA1797 also inhibits ASK1 (IC50 value 0.65 μM for inhibition of apoptosis signal-regulating kinase 1).

PH Cha et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.

PH Cha et al. Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer. BMB Rep. 2016 Sep;49(9):455-6.

GP Volynets et al. Rational design of apoptosis signal-regulating kinase 1 inhibitors: discovering novel structural scaffold. Eur J Med Chem. 2013 Mar;61:104-15.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell Wnt-β-Catenin PI3K-Akt-mTOR Wnt

Promotor of β-catenin and Ras degradation that effectively suppresses the growth of CRCs

Chemical name

potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate

Parent CAS No.

[851304-36-4]

產(chǎn)品資料

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