| 產(chǎn)品名稱 | SB 525334 |
| 產(chǎn)品貨號(hào) | Axon 2285 CAS [356559-20-1] MF C21H21N5MW 343.42 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of the ALK5 receptor (IC50 value 14.3 nM). SB 525334 is approximately 4-fold less potent as an inhibitor of ALK4, and inactive as an inhibitor of ALK2, ALK3, and ALK6. In cell-based assays, SB 525334 blocked TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in renal epithelial carcinoma cells. References Certificates Categories Extra info O. Fuchs. Inhibition of TGF-β signaling for the treatment of tumor metastasis and fibrotic diseases. Curr. Signal Trans. Ther. 2011, 6, 29-43. ? N.J. Laping et al. Tumor-Specific Efficacy of Transforming Growth Factor-βRI Inhibition in Eker Rats. Clin. Cancer Res. 2007, 13, 3087-3099. ? E.T. Grygielko et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J. Pharmacol. Exp. Ther. 2005, 313, 943-951. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class I; EC 2.7.11.30 TGF-βR Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor Chemical name 6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline Parent CAS No. [356559-20-1] Order Size Unit Price Stock 10 mg €105.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
SB 525334Axon 2285 CAS [356559-20-1] MF C21H21N5
Description
Potent and selective inhibitor of the ALK5 receptor (IC50 value 14.3 nM). SB 525334 is approximately 4-fold less potent as an inhibitor of ALK4, and inactive as an inhibitor of ALK2, ALK3, and ALK6.
In cell-based assays, SB 525334 blocked TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in renal epithelial carcinoma cells.
Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor
Chemical name6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline Parent CAS No.[356559-20-1] |
| 產(chǎn)品資料 |
