<button id="eiezk"><video id="eiezk"></video></button>

產(chǎn)品名稱

ML348

產(chǎn)品貨號

Axon 2646 CAS [899713-86-1] MF C18H17ClF3N3O3MW 415.79 Purity: 99% Soluble in DMSO Description Selective and in vivo active inhibitor for acyl-protein thioesterase APT1 (IC50 values 0.84 μM and >10 μM for APT1 and APT2, respectively; Ki values 280 nM and >10000 nM for WT APT1 and APT2, respectively). A useful tool to study LYPLA/APT mediated protein S-palmitoylation and related pharmacology. In some of the literature, APT1 and APT2 are also identified as lysophospholipases LYPLA1 and LYPLA2 as they were first discovered due to their ability to hydrolyze various lysophospholipids. KEYWORDS:?ML348 | supplier | APT1 inhibitor | ML-348 | CAS [899713-86-1] | S-palmitoylated proteins | APT | acyl-protein thioesterase | LYPLA | APT2 | LYPLA1 | LYPLA2 | lysophospholipids

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ML348

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2646

CAS [899713-86-1]

MF C18H17ClF3N3O3
MW 415.79

Purity: 99%
Soluble in DMSO

ML348

Description

Selective and in vivo active inhibitor for acyl-protein thioesterase APT1 (IC50 values 0.84 μM and >10 μM for APT1 and APT2, respectively; Ki values 280 nM and >10000 nM for WT APT1 and APT2, respectively). A useful tool to study LYPLA/APT mediated protein S-palmitoylation and related pharmacology. In some of the literature, APT1 and APT2 are also identified as lysophospholipases LYPLA1 and LYPLA2 as they were first discovered due to their ability to hydrolyze various lysophospholipids.

I Vujic et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.

JJ Hulce et al. An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): NCBI (US); 2010-2013 Dec 09?

SJ Won et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol. 2016 Oct 31.

A Adibekian et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. J Am Chem Soc. 2012 Jun 27;134(25):10345-8.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS APT EC 3.1.2.22

Selective inhibitor for acyl-protein thioesterase APT1 (aka LYPLA1)

Chemical name

N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide

Parent CAS No.

[899713-86-1]

產(chǎn)品資料

<button id="eiezk"><video id="eiezk"></video></button>