| 產(chǎn)品名稱 | PTIQ |
| 產(chǎn)品貨號(hào) | Axon 2328 CAS [1032822-42-6] MF C13H17NO3MW 235.28 Purity: 99% Soluble in 0.1N NaOH(aq), DMSO, and Ethanol Description Brain penetrating neuroprotectant that attenuates MPTP induced motor deficits, prevents neurodegeneration and suppresses microglial activation in the substantia nigra. Mechanistically, PTIQ effectively suppresses expression of MMP-3 (IC50 value 60 nM in stressed dopaminergic cells), and NO production (IC50 value <100 μM in LPS stimulated BV-2 cells). PTIQ also inhibits IL-1β, TNF-α (IC50 value 6.5 μM) and COX-2 (IC50 value 9.3 μM) and blocked nuclear translocation of NF-κB, yet it shows no inhibition of hERG channels or CYP isozyme activities. References Certificates Categories Extra info H.J. Son et al. A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP. Br J Pharmacol. 2012 Apr;165(7):2213-27. ? J.W. Seo et al. Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur J Med Chem. 2008 Jun;43(6):1160-70. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology CNS Miscellaneous Pain & Inflammation EC 3.4.24.17 MMP Neuroprotectant with attenuating effects on MMP-3 expression Chemical name 1-(7-hydroxy-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one Parent CAS No. [1032822-42-6] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
PTIQAxon 2328 CAS [1032822-42-6] MF C13H17NO3
Description
Brain penetrating neuroprotectant that attenuates MPTP induced motor deficits, prevents neurodegeneration and suppresses microglial activation in the substantia nigra. Mechanistically, PTIQ effectively suppresses expression of MMP-3 (IC50 value 60 nM in stressed dopaminergic cells), and NO production (IC50 value <100 μM in LPS stimulated BV-2 cells). PTIQ also inhibits IL-1β, TNF-α (IC50 value 6.5 μM) and COX-2 (IC50 value 9.3 μM) and blocked nuclear translocation of NF-κB, yet it shows no inhibition of hERG channels or CYP isozyme activities.
Neuroprotectant with attenuating effects on MMP-3 expression
Chemical name1-(7-hydroxy-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one Parent CAS No.[1032822-42-6] |
| 產(chǎn)品資料 |
