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產(chǎn)品名稱

LDN 212854 trihydrochloride

產(chǎn)品貨號

Axon 2201 CAS [2109414-80-2] MF C25H22N6.3HClMW 515.87 Purity: 99% Soluble in water and DMSO Description Potent ALK2-biased BMP type I receptor kinase inhibitor (IC50 values 2.4 nM, 1.3 nM, and 85.8 nM for ALK1, 2, and 3 resp.), showing nearly 4 orders of selectivity for BMP versus the closely related TGF-β and Activin type I receptors. Closely related to LDN 193189 (Axon 1509). KEYWORDS: LDN 212854 trihydrochloride | supplier | BMP inhibitor | LDN212854 | LDN-212854 | CAS [2109414-80-2] | [1432597-26-6] | TGF-β | BMP-ALK | ALK | type I | dorsomorphin | ALK2 | ALK-2 | ALK1 | ALK3 | bone morphogenetic protein | Antagonist | Receptors

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

LDN 212854 trihydrochloride

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2201

CAS [2109414-80-2]

MF C25H22N6.3HCl
MW 515.87

Purity: 99%
Soluble in water and DMSO

LDN 212854 trihydrochloride

Description

Potent ALK2-biased BMP type I receptor kinase inhibitor (IC50 values 2.4 nM, 1.3 nM, and 85.8 nM for ALK1, 2, and 3 resp.), showing nearly 4 orders of selectivity for BMP versus the closely related TGF-β and Activin type I receptors. Closely related to LDN 193189 (Axon 1509).

KEYWORDS: LDN 212854 trihydrochloride | supplier | BMP inhibitor | LDN212854 | LDN-212854 | CAS [2109414-80-2] | [1432597-26-6] | TGF-β | BMP-ALK | ALK | type I | dorsomorphin | ALK2 | ALK-2 | ALK1 | ALK3 | bone morphogenetic protein | Antagonist | Receptors

A.H. Mohedas et al. Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem. Biol. 2013. [Epub ahead of print].?

D.W. Engers et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of (...). Bioorg. Med. Chem. Lett. 2013, 23, 3248-3252.?

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class I; EC 2.7.11.30 BMP-ALK

Potent ALK2-biased BMP type I receptor kinase inhibitor

Chemical name

5-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline trihydrochloride

Parent CAS No.

[1432597-26-6]

產(chǎn)品資料

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