| 產(chǎn)品名稱 | AP 24534 - Ponatinib |
| 產(chǎn)品貨號(hào) | Axon 1857 CAS [943319-70-8] MF C29H27F3N6OMW 532.56 Purity: 98% Soluble in DMSO Description Potent and orally active tyrosine kinase inhibitor, targeting BCR-ABL and multiple RTK References Certificates Categories Extra info T?O'Hare et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009, 16(5), 401-412.? ? WS Huang et al. Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of (...). J. Med. Chem. 2010, 53(12), 4701-4719.? ? T Zhou et al. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem. Biol. Drug Des. 2011, 77(1), 1-11.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology BCR-ABL Oncogene Fusion Proteins EC 2.7.10.1 BCR-ABL kinase inhibitor (including T315I mutation) Chemical name 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Parent CAS No. [943319-70-8] Order Size Unit Price Stock 5 mg €90.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AP 24534 - PonatinibAxon 1857 CAS [943319-70-8] MF C29H27F3N6O
Description
Potent and orally active tyrosine kinase inhibitor, targeting BCR-ABL and multiple RTK
BCR-ABL kinase inhibitor (including T315I mutation)
Chemical name3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Parent CAS No.[943319-70-8] |
| 產(chǎn)品資料 |
