| 產(chǎn)品名稱 | GNF 2 |
| 產(chǎn)品貨號 | Axon 1882 CAS [778270-11-4] MF C18H13F3N4O2MW 374.32 Purity: 99% Soluble in DMSO Description Selective and allosteric inhibitor of Bcr-Abl tyrosine kinase, with IC50 of 267 nM and inactive at a panel of 63 other kinases, including native c-Abl; A new class of Bcr-Abl inhibitor to treat resistant Chronic myelogenous leukemia (CML) References Certificates Categories Extra info FJ Adrián et al. Allosteric inhibitors of Bcr-abl–dependent cell proliferation. Nature Chem. Biol. 2006, 2, 95-102.? ? J Zhang, FJ Adrián?et al. Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors. Nature 2010, 463, 501-506.? ? O Hantschel. Allosteric BCR-ABL inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukemia: novel opportunities for drug combinations to overcome resistance. Haematol. 2012, 97(2), 157-159.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology BCR-ABL Oncogene Fusion Proteins EC 2.7.10.1 Inhibitor of Bcr-Abl tyrosine kinase Chemical name 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide Parent CAS No. [778270-11-4] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
GNF 2Axon 1882 CAS [778270-11-4] MF C18H13F3N4O2
Description
Selective and allosteric inhibitor of Bcr-Abl tyrosine kinase, with IC50 of 267 nM and inactive at a panel of 63 other kinases, including native c-Abl; A new class of Bcr-Abl inhibitor to treat resistant Chronic myelogenous leukemia (CML)
Inhibitor of Bcr-Abl tyrosine kinase
Chemical name3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide Parent CAS No.[778270-11-4] |
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