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產(chǎn)品名稱

OTX 008 - PTX 008 | Calixarene 0118

產(chǎn)品貨號(hào)

Axon 2332 CAS [286936-40-1] MF C52H72N8O8MW 937.18 Purity: 99% Soluble in DMSO and Ethanol Description Selective allosteric inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumor angiogenesis. OTX008 inhibited galectin-1 expression and ERK1/2 and Akt-dependent survival pathways, and induced G2/M cell cycle arrest through CDK1. References Certificates Categories Extra info L. Astorgues-Xerri et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur. J. Cancer. 2014, 50, 2463-2477. ? M. Zucchetti et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother. Pharmacol. 2013, 72, 879-887. ? R.O. Dings et al. Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer. Invest. New Drugs. 2013, 31, 1142-1150. ? R.P. Dings et al. Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding. J. Med. Chem. 2012, 55, 5121-5129. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Immunology PI3K-Akt-mTOR Galectin Selective allosteric inhibitor of galectin-1 Chemical name 2,2',2'',2'''-[Pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-5,11,17,23-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-acetamide Parent CAS No. [286936-40-1] Order Size Unit Price Stock 5 mg €125.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

OTX 008 - PTX 008 | Calixarene 0118

Based on 9 publications in PubMed 10 10 9

Axon 2332

CAS [286936-40-1]

MF C52H72N8O8
MW 937.18

Purity: 99%
Soluble in DMSO and Ethanol

OTX 008

Description

Selective allosteric inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumor angiogenesis. OTX008 inhibited galectin-1 expression and ERK1/2 and Akt-dependent survival pathways, and induced G2/M cell cycle arrest through CDK1.

L. Astorgues-Xerri et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur. J. Cancer. 2014, 50, 2463-2477.

M. Zucchetti et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother. Pharmacol. 2013, 72, 879-887.

R.O. Dings et al. Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer. Invest. New Drugs. 2013, 31, 1142-1150.

R.P. Dings et al. Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding. J. Med. Chem. 2012, 55, 5121-5129.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Immunology PI3K-Akt-mTOR Galectin

Selective allosteric inhibitor of galectin-1

Chemical name

2,2',2'',2'''-[Pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-5,11,17,23-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-acetamide

Parent CAS No.

[286936-40-1]

產(chǎn)品資料

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