| 產品名稱 | GSK 2982772 |
| 產品貨號 | Axon 2713 CAS [1622848-92-3] MF C20H19N5O3MW 377.40 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description GSK2982772 potently binds to RIP1 with exquisite kinase specificity (IC50 value of 1.0 nM; ADP-Glo activity assay) and has excellent activity in blocking many TNF-dependent cellular responses (IC50 value of 6.3 nM; human monocytic U937 cellular assay). The inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. First-in-class RIP1 inhibitor to enter clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis. KEYWORDS: GSK 2982772 | supplier | RIP1 inhibitor | GSK-2982772 | GSK2982772 | CAS [1622848-92-3] | Non Selective (Phosphorylation Substrates) | RIP | Inhibitor | Enzymes |
| 產品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產品規(guī)格 | |
| 產品品牌 | axonmedchem |
| 產品概述 | |
| 產品詳情 |
GSK 2982772Axon 2713 CAS [1622848-92-3] MF C20H19N5O3
DescriptionGSK2982772 potently binds to RIP1 with exquisite kinase specificity (IC50 value of 1.0 nM; ADP-Glo activity assay) and has excellent activity in blocking many TNF-dependent cellular responses (IC50 value of 6.3 nM; human monocytic U937 cellular assay). The inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. First-in-class RIP1 inhibitor to enter clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis. KEYWORDS: GSK 2982772 | supplier | RIP1 inhibitor | GSK-2982772 | GSK2982772 | CAS [1622848-92-3] | Non Selective (Phosphorylation Substrates) | RIP | Inhibitor | Enzymes
Specific inhibitor of RIP1 kinase
Chemical name(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide Parent CAS No.[1622848-92-3] |
| 產品資料 |
