| 產(chǎn)品名稱 | JNJ 26481585 dihydrochloride - Quisinostat dihydrochloride |
| 產(chǎn)品貨號(hào) | Axon 2529 CAS [875320-31-3] MF C21H26N6O2.2HClMW 467.39 Purity: 99% Soluble in DMSO Description Potent, orally available second-generation pan-HDAC inhibitor (highest IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with activity in human leukemia. JNJ-26481585 induces continuous acetylation of histone H3, activation of the caspase cascade, and upregulation of p21, resulting in apoptosis and cell cycle arrest in the myeloma cells at low nanomolar concentrations. JNJ26481585 also potently induced tubulin acetylation. KEYWORDS: JNJ 26481585 HCl | supplier | HDAC inhibitor | Quisinostat dihydrochloride | JNJ26481585 | CAS [875320-31-3] | [875320-29-9] | Histone | HDAC | Inhibitor | HDAC1 | HDAC2 | HDAC4 | HDAC10 | HDAC11 | tubulin | epigenetic | apoptosis | leukemia | acetylation |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
JNJ 26481585 dihydrochloride - Quisinostat dihydrochlorideAxon 2529 CAS [875320-31-3] MF C21H26N6O2.2HCl
DescriptionPotent, orally available second-generation pan-HDAC inhibitor (highest IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with activity in human leukemia. JNJ-26481585 induces continuous acetylation of histone H3, activation of the caspase cascade, and upregulation of p21, resulting in apoptosis and cell cycle arrest in the myeloma cells at low nanomolar concentrations. JNJ26481585 also potently induced tubulin acetylation. KEYWORDS: JNJ 26481585 HCl | supplier | HDAC inhibitor | Quisinostat dihydrochloride | JNJ26481585 | CAS [875320-31-3] | [875320-29-9] | Histone | HDAC | Inhibitor | HDAC1 | HDAC2 | HDAC4 | HDAC10 | HDAC11 | tubulin | epigenetic | apoptosis | leukemia | acetylation
Potent, orally available second-generation pan-HDAC inhibitor
Chemical nameN-hydroxy-2-(4-(((1-methyl-1H-indol-3-yl)methylamino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride Parent CAS No.[875320-29-9] |
| 產(chǎn)品資料 |
