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產(chǎn)品名稱

ZLN 024

產(chǎn)品貨號

Axon 2445 CAS [723249-01-2] MF C13H13BrN2OSMW 325.22 Purity: 100% Soluble in DMSO Description Allosteric activator of AMP-activated protein kinase (AMPK; EC50 values 0.42 μM and 0.95 μM for increasing the activity of activated heterotrimers α1β1γ1 and α2β1γ1, respectively) that has no effect on mitochondrial function or the ADP/ATP ratio, and which exerts beneficial metabolic effects in vitro and in vivo. ZLN 024 reduced glucose intolerance and fatty liver characteristics in diabetic db/db mice and provides a promising therapeutic approach for type 2 diabetes mellitus and metabolic syndrome. References Certificates Categories Extra info L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Diabetes & Metabolism Epigenetics Stem Cell AMPK TGF-β MAPK PI3K-Akt-mTOR EC 2.7.11.31 Allosteric activator of AMP-activated protein kinase (AMPK) Chemical name 2-(2-(2-bromo-4-methylphenoxy)ethylthio)pyrimidine Parent CAS No. [723249-01-2] Order Size Unit Price Stock 10 mg €90.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ZLN 024

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2445

CAS [723249-01-2]

MF C13H13BrN2OS
MW 325.22

Purity: 100%
Soluble in DMSO

ZLN 024

Description

Allosteric activator of AMP-activated protein kinase (AMPK; EC50 values 0.42 μM and 0.95 μM for increasing the activity of activated heterotrimers α1β1γ1 and α2β1γ1, respectively) that has no effect on mitochondrial function or the ADP/ATP ratio, and which exerts beneficial metabolic effects in vitro and in vivo. ZLN 024 reduced glucose intolerance and fatty liver characteristics in diabetic db/db mice and provides a promising therapeutic approach for type 2 diabetes mellitus and metabolic syndrome.

L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Diabetes & Metabolism Epigenetics Stem Cell AMPK TGF-β MAPK PI3K-Akt-mTOR EC 2.7.11.31

Allosteric activator of AMP-activated protein kinase (AMPK)

Chemical name

2-(2-(2-bromo-4-methylphenoxy)ethylthio)pyrimidine

Parent CAS No.

[723249-01-2]

產(chǎn)品資料

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