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產(chǎn)品名稱

BHPI

產(chǎn)品貨號

Axon 2790 CAS [56632-39-4] MF C21H17NO3MW 331.36 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description BHPI is a potent noncompetitive ERα inhibitor that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells (IC50 values of 27 and 15 nM in MDA-468 and T47D cell lines, respectively). Moreover, BHPI induced rapid and substantial tumor regression in a mouse xenograft model of breast cancer. KEYWORDS: BHPI | supplier | ER-α antagonist | CAS [56632-39-4] | Estrogen | Estrogen (ER) | Antagonist | Receptors | Breast cancer

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BHPI

Based on 10 reference(s) in Google Scholar 8 10 10

Axon 2790

CAS [56632-39-4]

MF C21H17NO3
MW 331.36

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

BHPI

Description

BHPI is a potent noncompetitive ERα inhibitor that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells (IC50 values of 27 and 15 nM in MDA-468 and T47D cell lines, respectively). Moreover, BHPI induced rapid and substantial tumor regression in a mouse xenograft model of breast cancer.

MK Uddin et al. Syntheses and antiproliferative evaluation of oxyphenisatin derivatives. Bioorg Med Chem Lett. 2007 May 15;17(10):2854-7.

ND Andruska et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Endocrinology Estrogen (ER) NR3A

ER-α antagonist

Chemical name

3,3-Bis(4-hydroxyphenyl)-7-methylindolin-2-one

Parent CAS No.

[56632-39-4]

產(chǎn)品資料

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