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產(chǎn)品名稱

ITD-1, (+)-

產(chǎn)品貨號(hào)

Axon 2467 CAS [1409968-46-2] MF C27H29NO3MW 415.52 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description More active (+)-enantiomer of ITD 1 (Axon 2323),?a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (?)-ITD 1, respectively for TGF-β inhibition) that acts by clearing the type II TGFβ receptor from the cell surface. ITD 1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-enantiomer is approximately 15-fold more effective than by its (?)-enantiomer. KEYWORDS: (+)-ITD-1 | supplier | TGF-βR2 inhibitor | ITD1 | (+)-ITD1 | CAS [1409968-46-2] | [1099644-42-4] | [1217467-13-4] | TGF-β | TGF-βR | Antagonist | active enantiomer | Smad | differentiation | cardiomyocytes | cardiogenesis | mESC | stem cell

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ITD-1, (+)-

Based on 16 publications in PubMed 9 10 16

Axon 2467

CAS [1409968-46-2]

MF C27H29NO3
MW 415.52

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

ITD-1, (+)-

Description

More active (+)-enantiomer of ITD 1 (Axon 2323),?a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (?)-ITD 1, respectively for TGF-β inhibition) that acts by clearing the type II TGFβ receptor from the cell surface. ITD 1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-enantiomer is approximately 15-fold more effective than by its (?)-enantiomer.

D. Schade et al. Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J. Med. Chem. 2012, 55, 9946-9957.

E. Willems et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012, 11, 242-252.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class II; EC 2.7.11.30 TGF-βR

Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis

Chemical name

(R)-ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Parent CAS No.

[1409968-46-2]

產(chǎn)品資料

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