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產(chǎn)品名稱

GW 788388

產(chǎn)品貨號

Axon 1832 CAS [452342-67-5] MF C25H23N5O2MW 425.48 Purity: 99% Soluble in DMSO Description Potent, orally active and selective inhibitor of transforming growth factor β receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5). KEYWORDS: GW 788388 | supplier | ALK5 inhibitor | GW788388 | GW-788388 | CAS [452342-67-5] | TGF-β | TGF-βR | Antagonist | Receptors

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

GW 788388

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1832

CAS [452342-67-5]

MF C25H23N5O2
MW 425.48

Purity: 99%
Soluble in DMSO

GW 788388

Description

Potent, orally active and selective inhibitor of transforming growth factor β receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).

KEYWORDS: GW 788388 | supplier | ALK5 inhibitor | GW788388 | GW-788388 | CAS [452342-67-5] | TGF-β | TGF-βR | Antagonist | Receptors

SM Tan et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2010, 298, H1415-1425.?

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F Gellibert et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor (...). J. Med. Chem. 2006, 49(7), 2210-2221.?

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M Petersen et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008, 73(6), 705-15.?

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class I; EC 2.7.11.30 TGF-βR

TGF-βR 1 inhibitor

Chemical name

4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

Parent CAS No.

[452342-67-5]

產(chǎn)品資料

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