| 產(chǎn)品名稱 | Azoramide |
| 產(chǎn)品貨號(hào) | Axon 2567 CAS [932986-18-0] MF C15H17ClN2OSMW 308.83 Purity: 99% Soluble in DMSO Description Small-molecule modulator of the unfolded protein response (UPR) with antidiabetic activity (IC50 value 8.826 μM for azoramide-induced increase of ASGR-Cluc secretion in HuH7 cells). Azoramide is a dual-function ER modulator that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Moreover, Azoramide improves insulin sensitivity and pancreatic β-cell function in multiple obese mouse preclinical models. KEYWORDS: Azoramide | supplier | UPR modulator | CAS [932986-18-0] | Unfolded Protein Response | endoplasmatic reticulum | ER stress | protein folding | PERK | IRE1 | ATF6 | obesity | antidiabetic | glucose |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AzoramideAxon 2567 CAS [932986-18-0] MF C15H17ClN2OS
DescriptionSmall-molecule modulator of the unfolded protein response (UPR) with antidiabetic activity (IC50 value 8.826 μM for azoramide-induced increase of ASGR-Cluc secretion in HuH7 cells). Azoramide is a dual-function ER modulator that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Moreover, Azoramide improves insulin sensitivity and pancreatic β-cell function in multiple obese mouse preclinical models. KEYWORDS: Azoramide | supplier | UPR modulator | CAS [932986-18-0] | Unfolded Protein Response | endoplasmatic reticulum | ER stress | protein folding | PERK | IRE1 | ATF6 | obesity | antidiabetic | glucose
Modulator of the unfolded protein response (UPR) with antidiabetic activity
Chemical nameN-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyramide Parent CAS No.[932986-18-0] |
| 產(chǎn)品資料 |
