| 產(chǎn)品名稱 | FH535 |
| 產(chǎn)品貨號 | Axon 2686 CAS [108409-83-2] MF C13H10Cl2N2O4SMW 361.20 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines. The water soluble sodium salt of FH535 is available as Axon 2706. KEYWORDS: FH535 | supplier | Dual Wnt/β-catenin and PPAR inhibitor | FH-535 | FH 535 | CAS [108409-83-2] | Metabolism | PPARγ | PPARδ | peroxisome proliferator–activated receptor | Nuclear | NR1C | Tcf/Lef |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
FH535Axon 2686 CAS [108409-83-2] MF C13H10Cl2N2O4S
DescriptionSmall-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines. The water soluble sodium salt of FH535 is available as Axon 2706. KEYWORDS: FH535 | supplier | Dual Wnt/β-catenin and PPAR inhibitor | FH-535 | FH 535 | CAS [108409-83-2] | Metabolism | PPARγ | PPARδ | peroxisome proliferator–activated receptor | Nuclear | NR1C | Tcf/Lef
Dual inhibitor of PPAR and Wnt/β-catenin signaling
Chemical name2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide Parent CAS No.[108409-83-2] |
| 產(chǎn)品資料 |
