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產(chǎn)品名稱

Apoptozole

產(chǎn)品貨號(hào)

Axon 2251 CAS [1054543-47-3] MF C33H25F6N3O3MW 625.56 Purity: 100% Soluble in DMSO Description An apoptosis-inducing small molecule that inhibits the ATPase activity of heat shock cognate 70 (Hsc70) and Hsp70 by binding to its ATPase domain (Kd values 0.21 and 0.14?μM for Hsc70 and Hsp70, respectively as determined by surface plasmon resonance (SPR) spectroscopy). Apoptozole has high cellular potency to restore the chloride channel activity of mutant CFTR by promoting its membrane trafficking. References Certificates Categories Extra info H.J. Cho et al. A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator. J. Am. Chem. Soc. 2011, 133, 20267-20276. ? D.R. Williams et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew. Chem. Int. Ed. Engl. 2008, 47, 7466-7469. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Pain & Inflammation Hsp70 Ubiquitin Hsc70 EC 3.6.1 Inhibitor of ATPase activity of Hsc70 and Hsp70 Chemical name 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide Parent CAS No. [1054543-47-3] Order Size Unit Price Stock 10 mg €95.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Apoptozole

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2251

CAS [1054543-47-3]

MF C33H25F6N3O3
MW 625.56

Purity: 100%
Soluble in DMSO

Apoptozole

Description

An apoptosis-inducing small molecule that inhibits the ATPase activity of heat shock cognate 70 (Hsc70) and Hsp70 by binding to its ATPase domain (Kd values 0.21 and 0.14?μM for Hsc70 and Hsp70, respectively as determined by surface plasmon resonance (SPR) spectroscopy). Apoptozole has high cellular potency to restore the chloride channel activity of mutant CFTR by promoting its membrane trafficking.

H.J. Cho et al. A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator. J. Am. Chem. Soc. 2011, 133, 20267-20276.

D.R. Williams et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew. Chem. Int. Ed. Engl. 2008, 47, 7466-7469.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Pain & Inflammation Hsp70 Ubiquitin Hsc70 EC 3.6.1

Inhibitor of ATPase activity of Hsc70 and Hsp70

Chemical name

4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide

Parent CAS No.

[1054543-47-3]

產(chǎn)品資料

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