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產(chǎn)品名稱

NVP-AUY922 - VER 52296 | Luminespib

產(chǎn)品貨號

Axon 1542 CAS [747412-49-3] MF C26H31N3O5MW 465.54 Purity: 98% Soluble in DMSO Description Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM References Certificates Categories Extra info MR Jensen et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 2008, 10, R33.? ? SA Eccles et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68, 2850.? ? PA Brough et al. 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. J. Med. Chem., 2008, 51 (2), pp 196–218.? ? T Taldone et al. Targeting Hsp90: small-molecule inhibitors and their clinical development. Cur. Opin. Pharmacol. 2008, 8(4), 370-374.? Certificate of Analysis Material Safety Data Sheet Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Hsp90 EC 3.6 Hsp90 inhibitor Chemical name 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide Parent CAS No. [747412-49-3] Order Size Unit Price Stock 5 mg €75.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

NVP-AUY922 - VER 52296 | Luminespib

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1542

CAS [747412-49-3]

MF C26H31N3O5
MW 465.54

Purity: 98%
Soluble in DMSO

NVP-AUY922

Description

Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM

MR Jensen et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 2008, 10, R33.?

SA Eccles et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68, 2850.?

PA Brough et al. 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. J. Med. Chem., 2008, 51 (2), pp 196–218.?

T Taldone et al. Targeting Hsp90: small-molecule inhibitors and their clinical development. Cur. Opin. Pharmacol. 2008, 8(4), 370-374.?

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Hsp90 EC 3.6

Hsp90 inhibitor

Chemical name

5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

Parent CAS No.

[747412-49-3]

產(chǎn)品資料

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