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產(chǎn)品名稱

TBOA ammonia salt, L- - TBOA | (3S)-3-(Phenylmethoxy)-L-aspartic acid ammonia salt

產(chǎn)品貨號(hào)

Axon 2427 CAS [N.A.] MF C11H13NO5.NH3MW 256.26 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Very potent blocker for the human excitatory amino acid transporters (EAAT1–3; IC50 values 23 μM, 3.8 μM, 7.0 μM for EAAT1, EAAT2, and EAAT3, respectively). L-TBOA is the most active isomer of DL-TBOA, as sold by competitors, and approximately twice as potent for inhibition of EAAT1 and EAAT2.

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TBOA ammonia salt, L- - TBOA | (3S)-3-(Phenylmethoxy)-L-aspartic acid ammonia salt

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2427

CAS [N.A.]

MF C11H13NO5.NH3
MW 256.26

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

TBOA ammonia salt, L-

Description

Very potent blocker for the human excitatory amino acid transporters (EAAT1–3; IC50 values 23 μM, 3.8 μM, 7.0 μM for EAAT1, EAAT2, and EAAT3, respectively). L-TBOA is the most active isomer of DL-TBOA, as sold by competitors, and approximately twice as potent for inhibition of EAAT1 and EAAT2.?

?	?	EAAT1	EAAT2	EAAT3
?	?	(IC₅₀?μM)	(IC₅₀?μM)	(IC₅₀?μM)
?	dl-TBOA	48 ± 4.1	7.0 ± 1.1	8.0 ± 1.9
?	l-TBOA	23 ± 4.4	3.8 ± 1.0	7.0 ± 1.5
?	d-TBOA	637 ± 175	64 ± 14	21 ± 2.3

IC₅₀?values of THA derivatives for blocking [¹⁴C]glutamate uptake in COS-1 cells expressing EAAT1–3 (data taken from?Shimamoto et al.)

K. Shimamoto et al. Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10.

H. Raj et al. Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids. Nat Chem. 2012 Apr 29;4(6):478-84.

J. de Villiers et al. Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of l-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker. ChemCatChem. 2015 Jul 3;7(13):1931-1934.

Certificate of Analysis
Material Safety Data Sheet

CNS EAAT

Very potent blocker of EAAT1–3

Chemical name

(2S,3S)-2-amino-3-(benzyloxy)succinic acid, ammonia salt

Parent CAS No.

[208706-75-6]

產(chǎn)品資料

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