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產(chǎn)品名稱

JNJ 55511118

產(chǎn)品貨號

Axon 2793 CAS [2036081-86-2] MF C14H8ClF3N2O2MW 328.67 Purity: 98% Soluble in DMSO Description Potent negative modulator of AMPA receptor containing TARP-γ8 (Ki value of 26 nM). JNJ 55511118 exhibits excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration. Tool for reversible AMPA receptor inhibition, particularly within the hippocampus, with potential therapeutic utility as an anticonvulsant or neuroprotectant. KEYWORDS: JNJ 55511118 | supplier | AMPA negative modulator | JNJ-55511118 | JNJ55511118 | CAS [2036081-86-2] | Glutamate | AMPA | Negative modulator | Ion Channels | TARP-γ8 | Neuroprotectant

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

JNJ 55511118

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2793

CAS [2036081-86-2]

MF C14H8ClF3N2O2
MW 328.67

Purity: 98%
Soluble in DMSO

JNJ 55511118

Description

Potent negative modulator of AMPA receptor containing TARP-γ8 (Ki value of 26 nM). JNJ 55511118 exhibits excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration. Tool for reversible AMPA receptor inhibition, particularly within the hippocampus, with potential therapeutic utility as an anticonvulsant or neuroprotectant.

MP Maher et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-?8. J Pharmacol Exp Ther. 2016 May;357(2):394-414.

Certificate of Analysis
Material Safety Data Sheet

CNS AMPA Unclassified

Negative modulator of AMPA receptor (TARP-γ8 selective)

Chemical name

5-(2-Chloro-6-(trifluoromethoxy)phenyl)-1H-benzo[d]imidazol-2(3H)-one

Parent CAS No.

[2036081-86-2]

產(chǎn)品資料

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