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產(chǎn)品名稱

TCN-201

產(chǎn)品貨號

Axon 2708 CAS [852918-02-6] MF C21H17ClFN3O4SMW 461.89 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description NMDA receptor antagonist selective for NR2A- over NR2B-containing receptors (pIC50 values of 6.8 and 4.3, respectively). The degree of inhibition produced by TCN 201 is dependent on the concentration of the GluN1-site co-agonist, glycine (or D-serine), and is independent of the glutamate concentration. TCN-201 is a negative allosteric modulator of glycine binding. KEYWORDS: TCN-201 | supplier | NR2A antagonist | TCN201 | TCN 201 | CAS [852918-02-6] | Axon Medchem | Axon 2708 | Glutamate | NMDA | Antagonist | Ion Channels

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TCN-201

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 2708

CAS [852918-02-6]

MF C21H17ClFN3O4S
MW 461.89

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

TCN-201

Description

NMDA receptor antagonist selective for NR2A- over NR2B-containing receptors (pIC50 values of 6.8 and 4.3, respectively). The degree of inhibition produced by TCN 201 is dependent on the concentration of the GluN1-site co-agonist, glycine (or D-serine), and is independent of the glutamate concentration. TCN-201 is a negative allosteric modulator of glycine binding.

E Bettini et al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther. 2010 Dec;335(3):636-44.

KB Hansen et al. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J Neurosci. 2012 May 2;32(18):6197-208.

S Edman et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.

Certificate of Analysis
Material Safety Data Sheet

CNS Pain & Inflammation NMDA Unclassified

NMDA NR2A antagonist

Chemical name

N-(4-(2-Benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamide

Parent CAS No.

[852918-02-6]

產(chǎn)品資料

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