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產(chǎn)品名稱

CHPG - (RS)?-?2-?Chloro-?5-?hydroxyphenylglycine | α-Amino-2-chloro-5-hydroxybenzeneacetic acid

產(chǎn)品貨號

Axon 2691 CAS [170846-74-9] MF C8H8ClNO3MW 201.61 Purity: 98% Soluble in DMSO Description The mGluR5 receptor agonist CHPG selectively activates mGluR5a receptors (EC50 value of 750 μM), compared to mGluR1α receptors, when expressed in CHO cells. CHPG also potentiates NMDA-induced depolarizations in rat hippocampal slices, and is suggested to act directly on mGluR5 in dopaminergic neurons to induce the release of DA. Also CHPG promotes proliferation of human embryonic cortical NSCs with activation of the MAPKs signaling pathway. KEYWORDS: CHPG | supplier | mGluR5 agonist | CAS [170846-74-9] | Glutamate | mGluR5 | Agonist | Receptors | CAS [1303993-73-8] | CHO | Hippocampus

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CHPG - (RS)?-?2-?Chloro-?5-?hydroxyphenylglycine | α-Amino-2-chloro-5-hydroxybenzeneacetic acid

Based on 111 reference(s) in Google Scholar 8 10 111

Axon 2691

CAS [170846-74-9]

MF C8H8ClNO3
MW 201.61

Purity: 98%
Soluble in DMSO

CHPG

Description

The mGluR5 receptor agonist CHPG selectively activates mGluR5a receptors (EC50 value of 750 μM), compared to mGluR1α receptors, when expressed in CHO cells. CHPG also potentiates NMDA-induced depolarizations in rat hippocampal slices, and is suggested to act directly on mGluR5 in dopaminergic neurons to induce the release of DA. Also CHPG promotes proliferation of human embryonic cortical NSCs with activation of the MAPKs signaling pathway.

AJ Doherty et al. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 1997 Feb;36(2):265-7.

L Zhao et al. mGluR5 specific agonist CHPG promotes proliferation of human neural stem cells. Shenjing Jiepouxue Zazhi (2014), 30(1), 7-12.

C Ferrada et al. The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels. Neuroreport. 2017 Jan 1;28(1):28-34.

Certificate of Analysis
Material Safety Data Sheet

CNS Stem Cell mGluR5 C3

mGluR5 agonist

Chemical name

2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid

Parent CAS No.

[170846-74-9]

產(chǎn)品資料

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