| 產(chǎn)品名稱 | AdipoRon |
| 產(chǎn)品貨號(hào) | Axon 2275 CAS [924416-43-3] MF C27H28N2O3MW 428.52 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Orally active small-molecule AdipoR agonist (Kd values 1.8 and 3.1?μM for AdipoR1 and AdipoR2 respectively) that exerts antidiabetic effects via activation of AMPK and PPAR-α pathways.AdipoRon ameliorated insulin resistance, glucose intolerance, and diabetes of genetically obese rodent model db/db mice, thereby prolonging the shortened lifespan of db/db mice on a high-fat diet. References Certificates Categories Extra info M. Okada-Iwabu et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013, 503, 493-499. ? Y.T. Ang et al. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J. Mol. Evol. 2005, 61, 372-380. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism PI3K-Akt-mTOR AdipoR1 AdipoR2 PAQR1 Orally active small-molecule AdipoR agonist Chemical name 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide Parent CAS No. [924416-43-3] Order Size Unit Price Stock 10 mg €80.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AdipoRonAxon 2275 CAS [924416-43-3] MF C27H28N2O3
Description
Orally active small-molecule AdipoR agonist (Kd values 1.8 and 3.1?μM for AdipoR1 and AdipoR2 respectively) that exerts antidiabetic effects via activation of AMPK and PPAR-α pathways.AdipoRon ameliorated insulin resistance, glucose intolerance, and diabetes of genetically obese rodent model db/db mice, thereby prolonging the shortened lifespan of db/db mice on a high-fat diet.
Orally active small-molecule AdipoR agonist
Chemical name2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide Parent CAS No.[924416-43-3] |
| 產(chǎn)品資料 |
