| 產(chǎn)品名稱 | KY 05009 |
| 產(chǎn)品貨號 | Axon 2395 CAS [1228280-29-2] MF C18H16N4O2SMW 352.41 Purity: 99% Soluble in DMSO Description Inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP-competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. Additionally, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin. References Certificates Categories Extra info J. Kim et al. A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells. PLoS One. 2014 Oct 22;9(10):e110180. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Wnt-β-Catenin NF-κB TGF-β MAPK EC 2.7.11.1 TNIK Inhibitor of TNIK that attenuates TGF-β1-mediated Wnt and Smad signaling Chemical name 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide Parent CAS No. [1228280-29-2] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
KY 05009Axon 2395 CAS [1228280-29-2] MF C18H16N4O2S
Description
Inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP-competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. Additionally, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin.
Inhibitor of TNIK that attenuates TGF-β1-mediated Wnt and Smad signaling
Chemical name5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide Parent CAS No.[1228280-29-2] |
| 產(chǎn)品資料 |
