| 產(chǎn)品名稱 | ICG 001 |
| 產(chǎn)品貨號 | Axon 1766 CAS [847591-62-2] MF C33H32N4O4MW 548.63 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Specific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer References Certificates Categories Extra info KH Emami et al. A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription. PNAS 2004, 101(34), 12682-12687. ? M Eguchi et al. ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Med. Chem. 2005, 1(5), 467-472. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Cell-Cell Adhesion Protein Wnt Specific inhibitor of Wnt/β-catenin signaling pathway Chemical name (6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrimido[1,2-a]pyrazine-1-carboxamide Parent CAS No. [780757-88-2 (relative stereochemistry; Scifinder names incorrectly) 847591-62-2 (absolute stereochemistry)] Order Size Unit Price Stock 5 mg €115.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ICG 001Axon 1766 CAS [847591-62-2] MF C33H32N4O4
Description
Specific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer
Specific inhibitor of Wnt/β-catenin signaling pathway
Chemical name(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrimido[1,2-a]pyrazine-1-carboxamide Parent CAS No.[780757-88-2 (relative stereochemistry; Scifinder names incorrectly) 847591-62-2 (absolute stereochemistry)] |
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