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產(chǎn)品名稱

CHIR 124

產(chǎn)品貨號

Axon 1636 CAS [405168-58-3] MF C23H22ClN5OMW 419.91 Purity: 98% Optical purity: >98% ee Soluble in 0.1N HCl(aq) and DMSO Description Potent, cell permeable and selective Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively). KEYWORDS:?CHIR 124 | supplier | CHK1 inhibitor | CHIR124 | CHIR-124 | CAS [405168-58-3] | DNA-RNA | CHK | Checkpoint | p53 | cell cycle | DNA damage | arrest | apoptosis

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CHIR 124

Based on 1120 reference(s) in Google Scholar 10 10 1120

Axon 1636

CAS [405168-58-3]

MF C23H22ClN5O
MW 419.91

Purity: 98%
Optical purity: >98% ee
Soluble in 0.1N HCl(aq) and DMSO

CHIR 124

Description

Potent, cell permeable and selective Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).

KEYWORDS:?CHIR 124 | supplier | CHK1 inhibitor | CHIR124 | CHIR-124 | CAS [405168-58-3] | DNA-RNA | CHK | Checkpoint | p53 | cell cycle | DNA damage | arrest | apoptosis

ZJ Ni et al. 4-(Aminoalkylamino)-3-benzimidazolequinolinones as potent CHK-1 inhibitors. Bioorg. Med. Chem. Lett. 2006, 16(12), 3121-3124.

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AN Tse et al. CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo. Clin. Cancer Res. 2007, 13, 591-602.

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Y Tao et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Cell Cycle. 2009, 8(8), 1196-205.

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JL Smith. Role of checkpoint kinase 1 in malignant melanoma. PhD thesis 2013, University of Glasgow, UK.

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List of publications using CHIR 124 (Axon 1636) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53-Tumor Suppression DNA-damage Response EC 2.7.11.1 CHK

CHK1 inhibitor

Chemical name

(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one

Parent CAS No.

[405168-58-3]

產(chǎn)品資料

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