| 產(chǎn)品名稱 | LEE 011 - Ribociclib |
| 產(chǎn)品貨號 | Axon 2273 CAS [1211441-98-3] MF C23H30N8OMW 434.54 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Orally bioavailable and highly selective small-molecule inhibitor of CDK4/6 (mean IC50 value 307 nM in sensitive neuroblastoma-derived cell lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. LEE 011 treatment of BE2C and IMR5 neuroblastoma cell lines with demonstrated sensitivity to CDK4/6 inhibition resulted in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. KEYWORDS:?LEE 011 | supplier | CDK4/6 inhibitor | Ribociclib | LEE011 | LEE-011 | CAS [1211441-98-3] | Cyclin Dependent | CDK4 | CDK6 | orally bioavailable | cell-cycle arrest | senescence | FOXM1 |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
LEE 011 - RibociclibAxon 2273 CAS [1211441-98-3] MF C23H30N8O
DescriptionOrally bioavailable and highly selective small-molecule inhibitor of CDK4/6 (mean IC50 value 307 nM in sensitive neuroblastoma-derived cell lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. LEE 011 treatment of BE2C and IMR5 neuroblastoma cell lines with demonstrated sensitivity to CDK4/6 inhibition resulted in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. KEYWORDS:?LEE 011 | supplier | CDK4/6 inhibitor | Ribociclib | LEE011 | LEE-011 | CAS [1211441-98-3] | Cyclin Dependent | CDK4 | CDK6 | orally bioavailable | cell-cycle arrest | senescence | FOXM1
Orally bioavailable and highly selective small-molecule inhibitor of CDK4/6
Chemical name7-cyclopentyl-N,N-dimethyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Parent CAS No.[1211441-98-3] |
| 產(chǎn)品資料 |
