| 產(chǎn)品名稱 | PTC 209 |
| 產(chǎn)品貨號(hào) | Axon 2420 CAS [315704-66-6] MF C17H13Br2N5OSMW 495.19 Purity: 99% Soluble in DMSO Description Inhibitor of the canonical self-renewal regulator BMI-1, a vital part of the polycomb repressive complex 1 (PRC1; IC50 value 0.5 μM for inhibition of UTR-mediated luciferase BMI-1 reporter expression). Treatment of primary colorectal cancer xenografts with PTC209 resulted in colorectal CIC loss with long-term and irreversible impairment of tumor growth. PTC-209 preferentially inhibits the proliferation of human lymphoma U937 and HT1080 tumor cells, and is less effective in primary human peripheral blood mononuclear cells and human hematopoietic stem cells. References Certificates Categories Extra info A. Kreso et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014 Jan;20(1):29-36. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Stem Cell Hedgehog Wnt-β-Catenin PI3K-Akt-mTOR DNA-damage Response Ubiquitin BMI-1 Inhibitor of the canonical self-renewal regulator BMI-1 Chemical name N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine Parent CAS No. [315704-66-6] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
PTC 209Axon 2420 CAS [315704-66-6] MF C17H13Br2N5OS
Description
Inhibitor of the canonical self-renewal regulator BMI-1, a vital part of the polycomb repressive complex 1 (PRC1; IC50 value 0.5 μM for inhibition of UTR-mediated luciferase BMI-1 reporter expression). Treatment of primary colorectal cancer xenografts with PTC209 resulted in colorectal CIC loss with long-term and irreversible impairment of tumor growth. PTC-209 preferentially inhibits the proliferation of human lymphoma U937 and HT1080 tumor cells, and is less effective in primary human peripheral blood mononuclear cells and human hematopoietic stem cells.
Inhibitor of the canonical self-renewal regulator BMI-1
Chemical nameN-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine Parent CAS No.[315704-66-6] |
| 產(chǎn)品資料 |
