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產(chǎn)品名稱(chēng)

AZD 5438

產(chǎn)品貨號(hào)

Axon 1966 CAS [602306-29-6] MF C18H21N5O2SMW 371.46 Purity: 99% Soluble in DMSO Description Potent and orally bioavailable inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC50: 16, 6, and 20 nM, respectively); AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC50: 0.2-1.7 mM) References Certificates Categories Extra info KF Byth et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol. Cancer Ther. 2009, 8(7), 1856-1866.? ? DS Boss et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients (...). Ann. Oncol. 2010, 21(4), 884-894.? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology p53-Tumor Suppression EC 2.7.11.22 CDK CDK inhibitor (1, 2, and 9 specific) Chemical name 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine Parent CAS No. [602306-29-6] Order Size Unit Price Stock 5 mg €80.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AZD 5438

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1966

CAS [602306-29-6]

MF C18H21N5O2S
MW 371.46

Purity: 99%
Soluble in DMSO

AZD 5438

Description

Potent and orally bioavailable inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC50: 16, 6, and 20 nM, respectively); AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC50: 0.2-1.7 mM)

KF Byth et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol. Cancer Ther. 2009, 8(7), 1856-1866.?

DS Boss et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients (...). Ann. Oncol. 2010, 21(4), 884-894.?

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology p53-Tumor Suppression EC 2.7.11.22 CDK

CDK inhibitor (1, 2, and 9 specific)

Chemical name

4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine

Parent CAS No.

[602306-29-6]

產(chǎn)品資料

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