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產(chǎn)品名稱

VX 680 - MK 0457 | Tozasertib

產(chǎn)品貨號(hào)

Axon 1540 CAS [639089-54-6] MF C23H28N8OSMW 464.59 Purity: 98% Soluble in DMSO Description Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases References Certificates Categories Extra info EA Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine? 10, 262 - 267 (2004)? ? GM Cheetham et al.?Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.? Cancer Lett. 2007, 251,? 323-329. ? FJ Giles et al.?MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.?Blood 2007, 109,? 500-502. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Aurora inhibitor (non-specific) Chemical name Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide Parent CAS No. [639089-54-6] Order Size Unit Price Stock 10 mg €60.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

VX 680 - MK 0457 | Tozasertib

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1540

CAS [639089-54-6]

MF C23H28N8OS
MW 464.59

Purity: 98%
Soluble in DMSO

VX 680

Description

Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases

EA Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine? 10, 262 - 267 (2004)?

GM Cheetham et al.?Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.? Cancer Lett. 2007, 251,? 323-329.

FJ Giles et al.?MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.?Blood 2007, 109,? 500-502.

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora

Aurora inhibitor (non-specific)

Chemical name

Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide

Parent CAS No.

[639089-54-6]

產(chǎn)品資料

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