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產(chǎn)品名稱

GSK 2193874

產(chǎn)品貨號

Axon 2742 CAS [1336960-13-4] MF C37H38BrF3N4OMW 691.62 Purity: 98% Soluble in DMSO Description GSK 2193874 is a potent, selective, and orally active TRPV4 channel blocker (IC50 values of 2 and 40 nM for rTRPV4 and hTRPV4, respectively). TRPV4 blockade with GSK 2193874 provided protection against the development of pulmonary edema and the resulting deficits in arterial oxygenation in heart failure models in vivo. KEYWORDS: GSK 2193874,supplier,TRPV4 antagonist,GSK2193874,GSK-2193874,CAS [1336960-13-4],Non Selective (Cations),TRPV4,Antagonist,Ion Channels,Pulmonary Edema

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

GSK 2193874

Based on 11 reference(s) in Google Scholar 8 10 11

Axon 2742

CAS [1336960-13-4]

MF C37H38BrF3N4O
MW 691.62

Purity: 98%
Soluble in DMSO

GSK 2193874

Description

GSK 2193874 is a potent, selective, and orally active TRPV4 channel blocker (IC50 values of 2 and 40 nM for rTRPV4 and hTRPV4, respectively). TRPV4 blockade with GSK 2193874 provided protection against the development of pulmonary edema and the resulting deficits in arterial oxygenation in heart failure models in vivo.

KEYWORDS: GSK 2193874,supplier,TRPV4 antagonist,GSK2193874,GSK-2193874,CAS [1336960-13-4],Non Selective (Cations),TRPV4,Antagonist,Ion Channels,Pulmonary Edema

N Kindon et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular CNS Unclassified TRPV4

Orally active TRPV4 antagonist

Chemical name

3-(1,4'-Bipiperidin-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide

Parent CAS No.

[1336960-13-4]

產(chǎn)品資料

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