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產(chǎn)品名稱

ABT 102

產(chǎn)品貨號(hào)

Axon 1504 CAS [808756-71-0] MF C21H24N4OMW 348.44 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptors (IC50 values to be 5-7 nM) under clinical trials; TRVP1 receptor antagonism is a promising approach for pain management References Certificates Categories Extra info CS Surowy et al. ABT-102 Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo. JPET 2008, 326(3), 879-888.? ? P Honore et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain. 2009, 142(1-2), 27-35. Certificate of Analysis Material Safety Data Sheet CNS Pain & Inflammation TRPV1 Unclassified TRPV1 antagonist Chemical name (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea Parent CAS No. [808756-71-0] Order Size Unit Price Stock 5 mg €90.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ABT 102

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1504

CAS [808756-71-0]

MF C21H24N4O
MW 348.44

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

ABT 102

Description

Potent and selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptors (IC50 values to be 5-7 nM) under clinical trials; TRVP1 receptor antagonism is a promising approach for pain management

CS Surowy et al. ABT-102 Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo. JPET 2008, 326(3), 879-888.?

P Honore et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain. 2009, 142(1-2), 27-35.

Certificate of Analysis
Material Safety Data Sheet

CNS Pain & Inflammation TRPV1 Unclassified

TRPV1 antagonist

Chemical name

(R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea

Parent CAS No.

[808756-71-0]

產(chǎn)品資料

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