| 產(chǎn)品名稱 | FG-4592 - Roxadustat | ASP 1517 |
| 產(chǎn)品貨號(hào) | Axon 2588 CAS [808118-40-3] MF C19H16N2O5MW 352.34 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description New-generation oral HIF-PHD inhibitor (IC50 value 591 nM for inhibition of PHD2 in a fluorescence polarization assay) for the treatment of anemia in patients with chronic kidney disease (CKD) by promoting erythropoiesis. FG 4592 (Roxadustat) treatment significantly inhibited tert-Butyl hydroperoxide (TBHP)-induced apoptosis and increases the survival of neuronal PC-12 cells by stabilization of HIF-1α. FG 4592 is also shown to inhibit Fat Mass and Obesity Associated Protein (FTO; IC50 value 9.8 μM). KEYWORDS: FG-4592 | supplier | HIFα-PHD inhibitor | Roxadustat | ASP 1517 | FG4592 | ASP1517 | CAS [808118-40-3] | Hypoxia-signaling cascade | PHD-2 (HIF1) | Inhibitor | PHD2 | anemia | chronic kidney disease | CKD | erythropoiesis | survival | HIF-1α | Fat | Obesity Associated Protein | FTO |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
FG-4592 - Roxadustat | ASP 1517Axon 2588 CAS [808118-40-3] MF C19H16N2O5
DescriptionNew-generation oral HIF-PHD inhibitor (IC50 value 591 nM for inhibition of PHD2 in a fluorescence polarization assay) for the treatment of anemia in patients with chronic kidney disease (CKD) by promoting erythropoiesis. FG 4592 (Roxadustat) treatment significantly inhibited tert-Butyl hydroperoxide (TBHP)-induced apoptosis and increases the survival of neuronal PC-12 cells by stabilization of HIF-1α. FG 4592 is also shown to inhibit Fat Mass and Obesity Associated Protein (FTO; IC50 value 9.8 μM). KEYWORDS: FG-4592 | supplier | HIFα-PHD inhibitor | Roxadustat | ASP 1517 | FG4592 | ASP1517 | CAS [808118-40-3] | Hypoxia-signaling cascade | PHD-2 (HIF1) | Inhibitor | PHD2 | anemia | chronic kidney disease | CKD | erythropoiesis | survival | HIF-1α | Fat | Obesity Associated Protein | FTO
New-generation oral HIF-PHD inhibitor
Chemical name#NUM! Parent CAS No.[808118-40-3] |
| 產(chǎn)品資料 |
