| 產(chǎn)品名稱 | LW6 |
| 產(chǎn)品貨號 | Axon 2480 CAS [934593-90-5] MF C26H29NO5MW 435.51 Purity: 99% Soluble in DMSO Description Novel HIF-1 inhibitor (IC50 value 2.44 μM) that promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Lindau (VHL), without affecting the activity of prolyl hydroxylase (PHD). Evidence was found that identified MDH2 as a target protein of LW-6.?Moreover, LW6 suppresses angiogenesis by inhibition of HIF-1α stability via direct binding with calcineurin b homologous protein 1 (CHP1) in a Ca2+ dependent manner. KEYWORDS: LW 6 | supplier | HIF-1 inhibitor | LW6 | CAS [934593-90-5] | DNA-RNA | HIF-1 | CHP1 | Inhibitor | Transcription Factor | hypoxia inducible factor | angiogenesis | tumor | cancer | von-Hippel-Lindau | VHL | prolyl hydroxylase | PHD | calcineurin b homologous protein 1 | endoplasmic reticulum | malate d |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
LW6Axon 2480 CAS [934593-90-5] MF C26H29NO5
DescriptionNovel HIF-1 inhibitor (IC50 value 2.44 μM) that promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Lindau (VHL), without affecting the activity of prolyl hydroxylase (PHD). Evidence was found that identified MDH2 as a target protein of LW-6.?Moreover, LW6 suppresses angiogenesis by inhibition of HIF-1α stability via direct binding with calcineurin b homologous protein 1 (CHP1) in a Ca2+ dependent manner. KEYWORDS: LW 6 | supplier | HIF-1 inhibitor | LW6 | CAS [934593-90-5] | DNA-RNA | HIF-1 | CHP1 | Inhibitor | Transcription Factor | hypoxia inducible factor | angiogenesis | tumor | cancer | von-Hippel-Lindau | VHL | prolyl hydroxylase | PHD | calcineurin b homologous protein 1 | endoplasmic reticulum | malate dehydrogenase?2 |?MDH2
Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1
Chemical namemethyl 3-[[2-[4-(1-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate Parent CAS No.[934593-90-5] |
| 產(chǎn)品資料 |
