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產(chǎn)品名稱

AS 1842856

產(chǎn)品貨號(hào)

Axon 2839 CAS [836620-48-5] MF C18H22FN3O3MW 347.38 Purity: 99% Soluble in DMSO Description AS 1842856 is an orally active, potent and selective inhibitor of Forkhead box protein O1 transcription factor (IC50 value of 33 nM). AS 1842856 reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. Therapeutic drug for treating type 2 diabetes. KEYWORDS: AS 1842856 | supplier | FOXO1 inhibitor | AS1842856 | AS-1842856 | CAS [836620-48-5] | DNA-RNA | FOXO1 | Inhibitor | Transcription Factors | Diabetes | Forkhead box protein O1 transcription factor

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AS 1842856

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2839

CAS [836620-48-5]

MF C18H22FN3O3
MW 347.38

Purity: 99%
Soluble in DMSO

AS 1842856

Description

AS 1842856 is an orally active, potent and selective inhibitor of Forkhead box protein O1 transcription factor (IC50 value of 33 nM). AS 1842856 reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. Therapeutic drug for treating type 2 diabetes.

T Nagashima et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78(5):961-70.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Diabetes & Metabolism Transcription Factors TF class 3.3.1 FOXO1

Inhibitor of the Forkhead box protein O1 (FOXO1)

Chemical name

5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Parent CAS No.

[836620-48-5]

產(chǎn)品資料

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