<button id="eiezk"><video id="eiezk"></video></button>

產(chǎn)品名稱

CCT251236

產(chǎn)品貨號(hào)

Axon 2699 CAS [1693731-40-6] MF C32H32N4O5MW 552.62 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Highly potent, orally bioavailable inhibitor of the HSF1 stress pathway. CCT251236 displayed the desired balance of in vitro properties, while maintaining excellent cellular activity for inhibition of HSF1-mediated HSP72 induction (IC50 value of 19 nM). Moreover, CCT251236 displayed efficacy in a human ovarian carcinoma xenograft model. Promising chemical probe to investigate the role of HSF1 pathway inhibition and pirin binding in vitro and in vivo. KEYWORDS: CCT251236 | supplier | HSF1 inhibitor | CCT 251236 | CCT-251236 | CAS [1693731-40-6] | DNA-RNA | HSF1 | Inhibitor | Transcription Factors | HSP72 | Pirin

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CCT251236

Based on 2 reference(s) in Google Scholar 9 10 2

Axon 2699

CAS [1693731-40-6]

MF C32H32N4O5
MW 552.62

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

CCT251236

Description

Highly potent, orally bioavailable inhibitor of the HSF1 stress pathway. CCT251236 displayed the desired balance of in vitro properties, while maintaining excellent cellular activity for inhibition of HSF1-mediated HSP72 induction (IC50 value of 19 nM). Moreover, CCT251236 displayed efficacy in a human ovarian carcinoma xenograft model. Promising chemical probe to investigate the role of HSF1 pathway inhibition and pirin binding in vitro and in vivo.

KEYWORDS: CCT251236 | supplier | HSF1 inhibitor | CCT 251236 | CCT-251236 | CAS [1693731-40-6] | DNA-RNA | HSF1 | Inhibitor | Transcription Factors | HSP72 | Pirin

MD Cheeseman et al. Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem. 2017 Jan 12;60(1):180-201.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Diabetes & Metabolism Epigenetics HSF Transcription Factors DNA-damage Response TF class 3.4.1

HSF1 stress pathway inhibitor

Chemical name

N-(5-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide

Parent CAS No.

[1693731-40-6]

產(chǎn)品資料

<button id="eiezk"><video id="eiezk"></video></button>