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產(chǎn)品名稱(chēng)

AZD 1152-HQPA

產(chǎn)品貨號(hào)

Axon 1580 CAS [722544-51-6] MF C26H30FN7O3MW 507.56 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases. The dihydrogen phosphate prodrug, AZD 1152 (Barasertib), is converted rapidly to active AZD1152-HQPA in plasma References Certificates Categories Extra info RW Wilkinson et al. AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis. Clin. Cancer Res. 2007 13(12), 3682-3688. ? N Keen et al. Biological characterisation of AZD1152, a highly potent and selective inhibitor of aurora kinase activity. Clin. Cancer Res. 2005, 11, B220. ? E Walsby et al. Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica 2008,?93(5), 662-669. ? Y Tao et al. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 2008, 27, 3244-3255.? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Aurora B inhibitor Chemical name 2-[5-(7-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-propoxy}-quinazolin-4-ylamino)-1H-pyrazol-3-yl]-N-(3-fluoro-phenyl)-acetamide Parent CAS No. [722544-51-6] Order Size Unit Price Stock 5 mg €85.00 In Stock

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現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AZD 1152-HQPA

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1580

CAS [722544-51-6]

MF C26H30FN7O3
MW 507.56

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

AZD 1152-HQPA

Description

AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases. The dihydrogen phosphate prodrug, AZD 1152 (Barasertib), is converted rapidly to active AZD1152-HQPA in plasma

RW Wilkinson et al. AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis. Clin. Cancer Res. 2007 13(12), 3682-3688.

N Keen et al. Biological characterisation of AZD1152, a highly potent and selective inhibitor of aurora kinase activity. Clin. Cancer Res. 2005, 11, B220.

E Walsby et al. Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica 2008,?93(5), 662-669.

Y Tao et al. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 2008, 27, 3244-3255.?

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora

Aurora B inhibitor

Chemical name

2-[5-(7-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-propoxy}-quinazolin-4-ylamino)-1H-pyrazol-3-yl]-N-(3-fluoro-phenyl)-acetamide

Parent CAS No.

[722544-51-6]

產(chǎn)品資料

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