| 產(chǎn)品名稱 | RQ 00203078 |
| 產(chǎn)品貨號(hào) | Axon 2498 CAS [1254205-52-1] MF C21H13ClF6N2O5SMW 554.85 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Selective, potent, and orally active TRPM8 antagonist (IC50 value 8.3 nM) that demonstrated excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration. References Certificates Categories Extra info M. Ohmi et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8. Certificate of Analysis Material Safety Data Sheet CNS Miscellaneous Pain & Inflammation Unclassified TRPM8 Selective, potent, and orally active TRPM8 antagonist with in vivo activity Chemical name 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid Parent CAS No. [1254205-52-1] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
RQ 00203078Axon 2498 CAS [1254205-52-1] MF C21H13ClF6N2O5S
Description
Selective, potent, and orally active TRPM8 antagonist (IC50 value 8.3 nM) that demonstrated excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration.
Selective, potent, and orally active TRPM8 antagonist with in vivo activity
Chemical name4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid Parent CAS No.[1254205-52-1] |
| 產(chǎn)品資料 |
