| 產(chǎn)品名稱 | ZM 447439 |
| 產(chǎn)品貨號(hào) | Axon 1541 CAS [331771-20-1] MF C29H31N5O4MW 513.59 Purity: 99% Soluble in DMSO Description Selective and ATP-competitive inhibitor of Aurora B kinase in vitro, with IC50 values to be 50, 250 and 1000 nM for Aurora B, C and A kinases respectively References Certificates Categories Extra info BB Gadea and JV Ruderman. Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint. Mol. Biol. Cell 2005, 16(3), 1305-1318.? ? AA Dar et al. Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics? Mol. Cancer Ther. 2010, 9(2), 268 - 278.? ? F Girdler?et al.?Validating Aurora B as an anti-cancer drug target. J. Cell. Sci. 2006, 119, 3664-75. ? C Ditchfield et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell. Biol. 2003,?161(2), 267-80. ? I Georgieva et al. ZM447439, A novel promising aurora kinase inhibitor, Provokes antiproliferative and proapoptotic effects alone and in combination with Bio- and chemotherapeutic agents... Neuroendocrinol. 2010, 91(2), 121-130. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Aurora B inhibitor Chemical name N-{4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-ylamino]-phenyl}-benzamide Parent CAS No. [331771-20-1] Order Size Unit Price Stock 5 mg €85.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ZM 447439Axon 1541 CAS [331771-20-1] MF C29H31N5O4
Description
Selective and ATP-competitive inhibitor of Aurora B kinase in vitro, with IC50 values to be 50, 250 and 1000 nM for Aurora B, C and A kinases respectively
Aurora B inhibitor
Chemical nameN-{4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-ylamino]-phenyl}-benzamide Parent CAS No.[331771-20-1] |
| 產(chǎn)品資料 |
