| 產(chǎn)品名稱 | GNF 5837 |
| 產(chǎn)品貨號 | Axon 2248 CAS [1033769-28-6] MF C28H21F4N5O2MW 535.49 Purity: 99% Soluble in DMSO Description Potent, selective, and orally bioavailable tropomyosin receptor kinase (TRK) inhibitor with efficacy in rodent cancer tumor models (IC50 values 11, 9, and 7 nM for TRK A, B and C respectively in cellular Ba/F3 assay). Up to 100% tumor regression was observed in tumor xenografts derived from RIE cells expressing both TRKA and NGF. References Certificates Categories Extra info P. Albaugh et al. Discovery of GNF 5837, a selective TRK inhibitor with efficacy in rodent cancer tumor models. ACS Med. Chem. Lett. 2012, 3 (2), 140–145. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology RTK class VII; EC 2.7.10.1 Trk Potent, selective, and orally bioavailable tropomyosin receptor kinase (Trk) inhibitor Chemical name 1-(3-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-ylamino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea Parent CAS No. [1033769-28-6] Order Size Unit Price Stock 5 mg €90.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
GNF 5837Axon 2248 CAS [1033769-28-6] MF C28H21F4N5O2
Description
Potent, selective, and orally bioavailable tropomyosin receptor kinase (TRK) inhibitor with efficacy in rodent cancer tumor models (IC50 values 11, 9, and 7 nM for TRK A, B and C respectively in cellular Ba/F3 assay). Up to 100% tumor regression was observed in tumor xenografts derived from RIE cells expressing both TRKA and NGF.
Potent, selective, and orally bioavailable tropomyosin receptor kinase (Trk) inhibitor
Chemical name1-(3-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-ylamino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea Parent CAS No.[1033769-28-6] |
| 產(chǎn)品資料 |
