| 產(chǎn)品名稱 | Rigosertib sodium - ON01910 sodium | Estybon |
| 產(chǎn)品貨號 | Axon 2950 CAS [592542-60-4] MF C21H24NNaO8SMW 473.47 Purity: 99% Soluble in water and DMSO Recently added |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Rigosertib sodium - ON01910 sodium | EstybonAxon 2950 CAS [592542-60-4] MF C21H24NNaO8S
Recently added
DescriptionRigosertib sodium is a non-ATP-competitive inhibitor of PLK1 (IC50 value of 9–10 nM) which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis. In vitro studies with Rigosertib sodium showed that incubation of human leukemic cells with this compound results in the inhibition of PI3K/AKT pathway, down regulation of cyclin D1, induction of NOXA and BIM and activation of JNK pathway. In vivo, Rigosertib sodium did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models. KEYWORDS: Rigosertib sodium | supplier | PLK1 inhibitor | ON01910 sodium | Estybon | ON-01910 sodium | ON 01910 sodium | CAS [592542-60-4] | [592542-59-1] | Non Selective (CHK2; p53) | PLK | Inhibitor | Enzymes | Novonex | ON 01910.Na
Non-ATP-competitive PLK1 inhibitor
Chemical nameSodium (E)-2-(2-methoxy-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)phenylamino)acetate Parent CAS No.[592542-59-1] |
| 產(chǎn)品資料 |
