| 產品名稱 | Gisadenafil besylate - UK 369003 | PF 01224715 |
| 產品貨號 | Axon 2218 CAS [334827-98-4] MF C22H31N7O5S.C7H8O3SMW 677.79 Purity: 99% Soluble in water and DMSO Description Potent and selective inhibitor of cGMP-specific PDE5 (IC50 value 1.23 nM) with improved selectivity over PDE6 (PDE5/6 selectivity value 117 and >3000-fold selectivity over other PDEs). Gisadenafil has the potential for oral bioavailability and dose-proportional pharmacokinetics. Close analogue of Sildenafil (Viagra; Axon 2046) References Certificates Categories Extra info D.J. Rawson et al. The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg. Med. Chem. 2012, 20, 498-509.? ? N.A.M. Tamimi et al. A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated (...). BJU Int. 2010, 106, 674–680.? Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Immunology EC 3.1.4.35 PDE Pfizer Licensed Products Potent and selective inhibitor of PDE5 Chemical name 5-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl)-3-ethyl-2-(2-methoxyethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one benzenesulfonate Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [334826-98-1] Order Size Unit Price Stock 10 mg €105.00 In Stock |
| 產品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產品規(guī)格 | |
| 產品品牌 | axonmedchem |
| 產品概述 | |
| 產品詳情 |
Gisadenafil besylate - UK 369003 | PF 01224715Axon 2218 CAS [334827-98-4] MF C22H31N7O5S.C7H8O3S
DescriptionPotent and selective inhibitor of cGMP-specific PDE5 (IC50 value 1.23 nM) with improved selectivity over PDE6 (PDE5/6 selectivity value 117 and >3000-fold selectivity over other PDEs). Gisadenafil has the potential for oral bioavailability and dose-proportional pharmacokinetics. Close analogue of Sildenafil (Viagra; Axon 2046)
Potent and selective inhibitor of PDE5
Chemical name5-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl)-3-ethyl-2-(2-methoxyethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one benzenesulfonate Source informationPfizer compound; Sold for research purposes under agreement from Pfizer Inc.Parent CAS No.[334826-98-1] |
| 產品資料 |
