產(chǎn)品名稱(chēng)

ABT 702

產(chǎn)品貨號(hào)

Axon 2289 CAS [214697-26-4] MF C22H19BrN6OMW 463.33 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description The first, non-nucleoside adenosine kinase (ADK) inhibitor (IC50 value 2 nM and 50 nM in cytosolic and intact cell assays, respectively). ABT702 is orally active to reduce pain and inflammation in animal models, yet found to be clastogenic in an in vitro Chinese Hamster micronucleus assay. KEYWORDS:?ABT 702 | supplier | ADK inhibitor | ABT702 | CAS [214697-26-4] | ATP | ADK | pain | inflammation | clastogenic | mutagenesis

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現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ABT 702

Based on 54 publications in PubMed 9 10 54

Axon 2289

CAS [214697-26-4]

MF C22H19BrN6O
MW 463.33

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

ABT 702

Description

The first, non-nucleoside adenosine kinase (ADK) inhibitor (IC50 value 2 nM and 50 nM in cytosolic and intact cell assays, respectively). ABT702 is orally active to reduce pain and inflammation in animal models, yet found to be clastogenic in an in vitro Chinese Hamster micronucleus assay.

C.H. Lee et al. Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J Med Chem. 2001 Jun 21;44(13):2133-8.

P.J. Hajduk et al. Design of adenosine kinase inhibitors from the NMR-based screening of fragments. J Med Chem. 2000 Dec 14;43(25):4781-6.

M.F. Jarvis et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory... J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.

E.A. Kowaluk et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory... J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Pain & Inflammation ADK EC 2.7.1.20

The first, non-nucleoside adenosine kinase (ADK) inhibitor

Chemical name

5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine

Parent CAS No.

[214697-26-4]

產(chǎn)品資料

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ABT 702

Description

Chemical name

Parent CAS No.