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產(chǎn)品名稱

Motolimod - VTX-2337 | VTX-378

產(chǎn)品貨號(hào)

Axon 2783 CAS [926927-61-9] MF C28H34N4O2MW 458.60 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Motolimod is a highly potent and selective TLR8 agonist (EC50 value of 100 nM). Motolimod directly activates myeloid dendritic cells, monocytes, and NK cells, resulting in the production of high levels of mediators including: TNFα, IL-12, and IFNγ, known to orchestrate adaptive antitumor responses. KEYWORDS: Motolimod | supplier | TLR8 agonist? | VTX-2337 | VTX-378 | VTX 2337 | VTX2337 | VTX 378 | VTX378 | CAS [926927-61-9] | DNA-RNA | TLR8 | Agonist | Receptors | Antitumor

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Motolimod - VTX-2337 | VTX-378

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 2783

CAS [926927-61-9]

MF C28H34N4O2
MW 458.60

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Motolimod

Description

Motolimod is a highly potent and selective TLR8 agonist (EC50 value of 100 nM). Motolimod directly activates myeloid dendritic cells, monocytes, and NK cells, resulting in the production of high levels of mediators including: TNFα, IL-12, and IFNγ, known to orchestrate adaptive antitumor responses.

KEYWORDS: Motolimod | supplier | TLR8 agonist? | VTX-2337 | VTX-378 | VTX 2337 | VTX2337 | VTX 378 | VTX378 | CAS [926927-61-9] | DNA-RNA | TLR8 | Agonist | Receptors | Antitumor

H Lu et al. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18(2):499-509.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology TLR8 TLR8

Highly potent and selective TLR8 agonist

Chemical name

(1E,4E)-2-Amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Parent CAS No.

[926927-61-9]

產(chǎn)品資料

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