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產(chǎn)品名稱

NM-PP1, 1-

產(chǎn)品貨號

Axon 1892 CAS [221244-14-0] MF C20H21N5MW 331.41 Purity: 99% Soluble in DMSO Description A potent tyrosine kinase inhibitor (TKI) of multiple targets, such as v-Src (IC50: 1 μM), c-Fyn (IC50: 0.6 μM), c-Abl (IC50: 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50: 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values approx 3 nM). References Certificates Categories Extra info AC Bishop et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 1999, 121 627-631 (1999). ? X. Chen et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005, 46, 13-21.? ? AC Bishop et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407 395-401.? ? T Sugi et al. Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step. Eukaryotic Cell 2010, 9(4), 667-670.? ? X Wang et al. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J. Neurosci. 2009, 29(17), 5508–5515.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology SRC ABL EC 2.7.10.2 CDK Trk Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) Chemical name 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Parent CAS No. [221244-14-0] Order Size Unit Price Stock 5 mg €95.00 In Stock

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

NM-PP1, 1-

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1892

CAS [221244-14-0]

MF C20H21N5
MW 331.41

Purity: 99%
Soluble in DMSO

NM-PP1, 1-

Description

A potent tyrosine kinase inhibitor (TKI) of multiple targets, such as v-Src (IC50: 1 μM), c-Fyn (IC50: 0.6 μM), c-Abl (IC50: 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50: 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values approx 3 nM).

AC Bishop et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 1999, 121 627-631 (1999).

X. Chen et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005, 46, 13-21.?

AC Bishop et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407 395-401.?

T Sugi et al. Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step. Eukaryotic Cell 2010, 9(4), 667-670.?

X Wang et al. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J. Neurosci. 2009, 29(17), 5508–5515.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology SRC ABL EC 2.7.10.2 CDK Trk

Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk)

Chemical name

1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Parent CAS No.

[221244-14-0]

產(chǎn)品資料

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