| 產(chǎn)品名稱 | OG-L002 hydrochloride |
| 產(chǎn)品貨號 | Axon 2077 CAS [1357298-75-9] MF C15H15NO.HClMW 261.75 Purity: 100% Soluble in water and DMSO Description Highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 μM). OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles. References Certificates Categories Extra info Y Liang et al. A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency. MBio. 2013, 4, e00558-12.? ? Inhibiting key protein halts herpes lytic cycle. mBioSphere on Feb 6, 2013. ? Z Watson et al. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses 2013, 5, 1740-1757.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Immunology EC 1.14.11 Histone demethylase Inhibitor of lysine specific demethylase 1 (LSD1 aka KDM1A) Chemical name 4'-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride Parent CAS No. [1357300-15-2] Order Size Unit Price Stock 5 mg €125.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
OG-L002 hydrochlorideAxon 2077 CAS [1357298-75-9] MF C15H15NO.HCl
Description
Highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 μM).
OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles.
Inhibitor of lysine specific demethylase 1 (LSD1 aka KDM1A)
Chemical name4'-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride Parent CAS No.[1357300-15-2] |
| 產(chǎn)品資料 |
