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產(chǎn)品名稱

LDK 378 - Ceritinib

產(chǎn)品貨號

Axon 2224 CAS [1032900-25-6] MF C28H36ClN5O3SMW 558.14 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor (IC50 value 0.2 nM) with >35 fold selectivity over InsR, IGF-1R. LDK 378 induced a dose-dependent tumor growth inhibition and tumor regression in multiple rat xenograft models. References Certificates Categories Extra info J. Chen et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J. Med. Chem. 2013, 56, 5673-5674.? ? T.H. Marsilje et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(...). J. Med. Chem. 2013, 56, 5675-5690.? ? E. Ardini et al. ALK Inhibitors, a Pharmaceutical Perspective. Front Oncol. 2012, 2, 17.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology ALK TGF-β RTK class XIX; 2.7.10.1 Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor Chemical name 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine Parent CAS No. [1032900-25-6] Order Size Unit Price Stock 5 mg €95.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

LDK 378 - Ceritinib

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2224

CAS [1032900-25-6]

MF C28H36ClN5O3S
MW 558.14

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

LDK 378

Description

Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor (IC50 value 0.2 nM) with >35 fold selectivity over InsR, IGF-1R. LDK 378 induced a dose-dependent tumor growth inhibition and tumor regression in multiple rat xenograft models.

J. Chen et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J. Med. Chem. 2013, 56, 5673-5674.?

T.H. Marsilje et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(...). J. Med. Chem. 2013, 56, 5675-5690.?

E. Ardini et al. ALK Inhibitors, a Pharmaceutical Perspective. Front Oncol. 2012, 2, 17.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology ALK TGF-β RTK class XIX; 2.7.10.1

Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor

Chemical name

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Parent CAS No.

[1032900-25-6]

產(chǎn)品資料

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